Selected Publications

NKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing

Gengqiang Xie, Maria Pilar Toledo, Xue Hu, Hyo Jeong Yong, Pamela Sandoval Sanchez, Chengyang Liu, Ali Naji, Jerome Irianto, Yue J. Wang

BMC Genomics, 2024.

Sex differences in the molecular programs of pancreatic cells contribute to the differential risks of type 2 diabetes

Hyo Jeong Yong, Maria Pilar Toledo, Richard S Nowakowski, Yue J. Wang

Endocrinology, 2022.

Increasing insulin measurement throughput by fluorescence anisotropy imaging immunoassays

Yao Wang, Damilola I. Adeoye, Yue J. Wang , Michael G. Roper 

Analytica Chimica Acta, 2022.

Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas

Hyo Jeong Yong, Gengqiang Xie, Chengyang Liu, Wei Wang, Ali Naji, Jerome Irianto, Yue J. Wang

Frontiers in Endocrinology, 2021.

Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver

Daniel Traum, Yue J. Wang, Kathleen B Schwarz, Jonathan Schug, David KH Wong, Harry LA Janssen, Norah A Terrault, Mandana Khalili, Abdus S Wahed, Karen F Murray, Phillip Rosenthal, Simon C Ling, Norberto Rodriguez-Baez, Richard K Sterling, Daryl TY Lau, Timothy M Block, Michael D Feldman, Elizabeth E Furth, William M Lee, David E Kleiner, Anna S Lok, Klaus H Kaestner, Kyong-Mi Chang

JCI insight, 2021.

Single cell transcriptomics of human islet ontogeny defines the molecular basis of β cell dedifferentiation in T2D.

Dana Avrahami, Yue J. Wang, Jonathan Schug, Eseye Feleke, Long Gao, Chengyang Liu, the HPAP Consortium, Ali Naji, Benjamin Glaser, Klaus H. Kaestner 

Molecular Metabolism, 2020.

The Dynamic Chromatin Architecture of the Regenerating Liver.

Amber W. Wang, Yue J. Wang, Adam M. Zahm, Ashleigh R. Morgan, Kirk J. Wangensteen, Klaus H. Kaestner

Cellular and Molecular Gastroenterology and Hepatology, 2020.

High-Content Screen Identifies MicroRNAs Required for Liver Repopulation After Injury in Mice.

Adam M. Zahm, Amber W. Wang, Yue J. Wang, Jonathan Schug, Kirk J. Wangensteen, Klaus H. Kaestner

Gastroenterology, 2019.

Comparative analysis of commercially available single-cell RNA sequencing platforms for their performance in complex human tissues.

Yue J. Wang, Jonathan Schug, Jerome Lin, Zhiping Wang, Andrew Kossenkov, The HPAP Consortium, Klaus H. Kaestner

BioRxiv, 2019.

Multiplexed in situ imaging mass cytometry analysis of the human endocrine pancreas and immune system in type 1 diabetes. 

Yue J. Wang, Daniel Traum, Jonathan Schug, Long Gao, Chengyang Liu, HPAP Consortium, Mark A. Atkinson, Alvin C. Powers, Michael D. Feldman

Ali Naji, Kyong-Mi Chang, Klaus H. Kaestner

Cell Metabolism. 2019. 

Single-Cell RNA-Seq of the Pancreatic Islets––a Promise Not yet Fulfilled?

Yue J.Wang, Klaus H.Kaestner

Cell Metabolism. 2019. 

Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication.

Kristy Ou, Ming Yu, Nicholas G. Moss, Yue J. Wang, Amber W. Wang, Son C. Nguyen, Connie Jiang, Eseye Feleke, Vasumathi Kameswaran, Eric F. Joyce, Ali Naji, Benjamin Glaser, Dana Avrahami, Klaus H. Kaestner

The Journal of Clinical Investigation. 2019. 

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.

Michal Shoshkes-Carmel, Yue J. Wang, Kirk J. Wangensteen, Beáta Tóth, Ayano Kondo, Efi E. Massasa, Shalev Itzkovitz, Klaus H. Kaestner 

Nature. 2018. 

TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury.

Amber W. Wang, Kirk J. Wangensteen, Yue J. Wang, Adam M. Zahm, Nicholas G. Moss, Noam Erez, Klaus H. Kaestner

The Journal of Clinical Investigation. 2018.

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.

Kirk J. Wangensteen, Yue J. Wang, Zhixun Dou, Amber W. Wang, Elham Mosleh‐Shirazi, Max A. Horlbeck, Luke A. Gilbert, Jonathan S. Weissman, Shelley L. Berger, Klaus H. Kaestner

Hepatology. 2017.

β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells.

Dana Avrahami, Yue J. Wang, Agnes Klochendler, Yuval Dor, Benjamin Glaser, Klaus H. Kaestner

Diabetes, Obesity and Metabolism. 2017.

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.

Yue J. Wang, Maria L. Golson, Jonathan Schug, Daniel Traum, Chengyang Liu, Kumar Vivek, Craig Dorrell, Ali Naji, Alvin C. Powers, Kyong-Mi Chang, Markus Grompe, Klaus H. Kaestner 

Cell Metabolism. 2016. 

Single-Cell Transcriptomics of the Human Endocrine Pancreas.

Yue J. Wang, Jonathan Schug, Kyoung-Jae Won, Chengyang Liu, Ali Naji, Dana Avrahami, Maria L. Golson, Klaus H. Kaestner

Diabetes. 2016.

A pancreatic exocrine-like cell regulatory circuit operating in the upper stomach of the sea urchin Strongylocentrotus purpuratus larva.

Margherita Perillo, Yue J. Wang, Steven D. Leach, Maria I. Arnone 

BMC Evolutionary Biology. 2016.

Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish.

Yue J. Wang, Joon T. Park, Michael J. Parsons, Steven D. Leach

Developmental Dynamics. 2015. 

Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia.

Yue J. Wang, Florencia McAllister, Jennifer M. Bailey, Sherri-Gae Scott, Audrey M. Hendley, Steven D. Leach, Bidyut Ghosh

Plos One. 2014.

Sphere-forming assays for assessment of benign and malignant pancreatic stem cells.

Yue J. Wang, Jennifer M. Bailey, Meritxell Rovira, Steven D. Leach

Pancreatic Cancer: Methods in Molecular Biology. 2013.